Gut Health

Morosil® and Weight Loss: What the 6-Month Trial Found

Written By: My Way Up® Editorial Team

Published at: 10/23/2026

Updated at: 10/23/2026

Losing weight takes real effort, and it’s fair to want to know whether a supplement will actually add anything to it. Here’s what a 6-month trial of Morosil® found, and what it means if you’re thinking of trying it.

In Short

In a 6-month clinical trial, overweight adults who took 400 mg of Morosil® a day while following a reduced-calorie diet and exercise program lost an average of 4.2% of their body weight. People following the same program with a placebo capsule lost 2.2%.

Lean Up Advanced is a stimulant-free weight management capsule by My Way Up®. It contains 400 mg of Morosil®, an extract of Moro blood oranges from Sicily, in each two-capsule daily serve, alongside Greenselect® Phytosome™, chromium and BioPerine®. It costs AUD $79.99.

Lean Up Advanced can only support weight loss when used alongside a reduced-calorie diet and increased physical activity.

What is Morosil®?

Morosil® is a branded extract of Moro blood oranges (Citrus sinensis) grown in Sicily. It is standardised for anthocyanins, the natural pigments that give blood oranges their deep red flesh.

In Lean Up Advanced, Morosil® is included because its anthocyanins support healthy body fat and muscle composition. Each 400 mg daily serve is equivalent to 60 g of fresh Citrus sinensis.

Because Morosil® is a branded ingredient, it is the same standardised extract used in the clinical research. A generic "blood orange extract" with a similar name may not be equivalent.

What did the 6-month Morosil® trial find?

People taking Morosil® lost nearly double the weight of people taking a placebo, with both groups following the same reduced-calorie diet and exercise program.

The double-blind study followed 98 overweight but otherwise healthy men and women, aged 20 to 65, for 6 months. One group took 400 mg of Morosil® a day, the same dose in Lean Up Advanced. The other took an identical-looking placebo capsule.

The Morosil® group lost an average of 4.2% of their body weight, compared with 2.2% on placebo. 36% of the Morosil® group lost more than 5% of their body weight, versus 22.5% on placebo. The difference first became significant at month four.

The study tested Morosil® on its own, not the full Lean Up Advanced formula. The figures are averages, so individual results vary, and they came from Morosil® combined with diet and exercise.

What to look for in a Morosil® supplement

Not every product that mentions blood orange matches the research, so check the label for a few things.

Look for Morosil® by name, not just "blood orange extract." The branded name tells you it's the standardised extract that was studied.

Check for 400 mg per daily serve, the dose used in the trial. Lean Up Advanced contains 400 mg in every two-capsule serve.

Look for absorption support. Lean Up Advanced includes BioPerine®, a clinically studied black pepper fruit extract, to enhance absorption of its other active ingredients.

Check whether the formula relies on stimulants. Feeling "switched on" from caffeine isn't the same as an ingredient doing what it was studied for. Lean Up Advanced contains no caffeine or other stimulants.

What else is in Lean Up Advanced?

Alongside 400 mg of Morosil®, each two-capsule serve contains three more ingredients.

Greenselect® Phytosome™ (99 mg, equivalent to 594 mg of dry Camellia sinensis) is a decaffeinated green tea catechin extract bound to a phospholipid. It supports thermogenesis, the body's natural production of heat from energy.

Chromium (50 mcg, as chromium picolinate) helps maintain healthy blood sugar levels in healthy individuals and aids glucose and carbohydrate metabolism.

BioPerine® (31.58 mg of black pepper fruit extract, equivalent to 647.39 mg of dry Piper nigrum) enhances the absorption of the other active ingredients.

What results can you realistically expect?

Changes are gradual, not overnight. In the Morosil® trial, the difference between the two groups first became significant at month four, and several customers say they first noticed a change at around 4 weeks. My Way Up® recommends taking Lean Up Advanced consistently for at least 90 days.

Lean Up Advanced works alongside your habits, not instead of them. Customers who see the best results tend to say the same thing: the supplement supports the effort, it doesn't do the work for you.

One customer, Tracy H., shared:

"I've been taking Lean Up Advanced for a few weeks now and I've noticed I don't get as many cravings for junk food and sugary food anymore. I also don't snack between meals now either."

Lean Up Advanced has an average rating of 4.65 out of 5 from 34 reviews, with 88% rating it 4 or 5 stars. Individual experiences vary.

How do you take Lean Up Advanced?

Take 2 vegan capsules each morning with breakfast. There's nothing to mix and only one dose a day.

How long: at least 90 days, taken consistently, for best results.
What to pair it with: a reduced-calorie diet and increased physical activity.
Who it's for: healthy adult women and men.
Stimulant-free: no caffeine or other stimulants.
Free from: sugar, gluten, dairy, animal products, soy, hormones, and artificial colours, flavours and preservatives.

Speak with your healthcare professional before use if you are pregnant or breastfeeding, take any prescription medicines, or have a pre-existing health condition.

Lean Up Advanced

Weight Loss + Weight Loss Maintenance

Supports metabolism + energy
For simple daily use in seconds
No stimulants or jitters
2 capsules daily

Try Lean Up Advanced

FAQ's

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Always read the label and follow directions for use.

Lean Up Advanced can only assist weight loss when used in conjunction with reduced calorie intake and increased physical activity in healthy individuals. Weight maintenance benefits apply to females. If symptoms persist, talk to your health professional. Vitamin and mineral supplements should not replace a balanced diet.